FSH Receptor est un gène codé par le symbole FSHR. D'autres noms incluent: Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; FSHR; LGR1. FSH Receptor a une masse de 78.27kDa, une longueur d'acide aminé de 695, et est impliqué dans les maladies: Ovarian dysgenesis 1; Ovarian hyperstimulation syndrome.
Nous proposons 11 des anticorps contre FSH Receptor, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).
Résumé Entrez
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Sertoli cells and ovarian granulosa cells.
Implication dans la maladie
Ovarian dysgenesis 1: An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Ovarian hyperstimulation syndrome: Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Modification post-traductionnelle
Sulfated.
Localisation cellulaire
Cell membrane.
