FPRL1 est un gène codé par le symbole FPR2. D'autres noms incluent: N-formyl peptide receptor 2; FMLP-related receptor I; FMLP-R-I; Formyl peptide receptor-like 1; HM63; Lipoxin A4 receptor; LXA4 receptor; RFP; FPR2; FPRH1; LXA4R. FPRL1 a une masse de 38.96kDa et une longueur d'acide aminé de 351.
Nous proposons 7 des anticorps contre FPRL1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).
Spécificité tissulaire
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Localisation cellulaire
Cell membrane.
Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized.
