FLI1 est un gène codé par le symbole FLI1. D'autres noms incluent: Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB. FLI1 a une masse de 50.98kDa, une longueur d'acide aminé de 452, et est impliqué dans les maladies: Ewing sarcoma; Bleeding disorder, platelet-type 21.
Nous proposons 27 des anticorps contre FLI1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Félin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Résumé Entrez
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Implication dans la maladie
Ewing sarcoma: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type 21: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
Similitudes de séquence
Belongs to the ETS family.
Localisation cellulaire
Nucleus.
