FGF19 est un gène codé par le symbole FGF19. D'autres noms incluent: Fibroblast growth factor 19; FGF-19. FGF19 a une masse de 24kDa et une longueur d'acide aminé de 216.
Nous proposons 3 des anticorps contre FGF19, élevé dans Lapin et Human, qui sont appropriés pour le WB, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Résumé Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Spécificité tissulaire
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Similitudes de séquence
Belongs to the heparin-binding growth factors family.
Localisation cellulaire
Secreted.
