ETS1 est un gène codé par le symbole ETS1. D'autres noms incluent: Protein C-ets-1; p54; EWSR2. ETS1 a une masse de 50.41kDa et une longueur d'acide aminé de 441.
Nous proposons 13 des anticorps contre ETS1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Résumé Entrez
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Spécificité tissulaire
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
Similitudes de séquence
Belongs to the ETS family.
Modification post-traductionnelle
Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.
Localisation cellulaire
Cytoplasm. Nucleus.
Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.
