Estrogen Sulfotransferase est un gène codé par le symbole SULT1E1. D'autres noms incluent: Sulfotransferase 1E1; ST1E1; EST-1; Sulfotransferase, estrogen-preferring; SULT1E1; STE. Estrogen Sulfotransferase a une masse de 35.13kDa et une longueur d'acide aminé de 294.
Nous proposons 7 des anticorps contre Estrogen Sulfotransferase, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
Résumé Entrez
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.
Spécificité tissulaire
Liver, intestine and at lower level in the kidney.
Similitudes de séquence
Belongs to the sulfotransferase 1 family.
Localisation cellulaire
Cytoplasm > Cytosol.
