EPX est un gène codé par le symbole EPX. D'autres noms incluent: Eosinophil peroxidase; EPO; EPER; EPP. EPX a une masse de 81.04kDa, une longueur d'acide aminé de 715, et est impliqué dans Eosinophil peroxidase deficiency.
Nous proposons 11 des anticorps contre EPX, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Résumé Entrez
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency.
Implication dans la maladie
Eosinophil peroxidase deficiency: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.
Similitudes de séquence
Belongs to the peroxidase family. XPO subfamily.
Localisation cellulaire
Cytoplasmic granule.
Cytoplasmic granules of eosinophils.
