Epac1 est un gène codé par le symbole RAPGEF3. D'autres noms incluent: Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; RAPGEF3; CGEF1; EPAC. Epac1 a une masse de 103.75kDa et une longueur d'acide aminé de 923.
Nous proposons 9 des anticorps contre Epac1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Cheval.
Informations sur les Gènes et les Protéines
Résumé UniProt
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Spécificité tissulaire
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Localisation cellulaire
Endomembrane system.
