Eotaxin est un gène codé par le symbole CCL11. D'autres noms incluent: C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; CCL11; SCYA11. Eotaxin a une masse de 10.73kDa et une longueur d'acide aminé de 97.
Nous proposons 9 des anticorps contre Eotaxin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Résumé Entrez
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Similitudes de séquence
Belongs to the intercrine beta (chemokine CC) family.
Modification post-traductionnelle
O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.
Localisation cellulaire
Secreted.
