eIF5A est un gène codé par le symbole EIF5A. D'autres noms incluent: Eukaryotic translation initiation factor 5A-1; eIF-5A-1; Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D. eIF5A a une masse de 16.83kDa et une longueur d'acide aminé de 154.
Nous proposons 8 des anticorps contre eIF5A, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Spécificité tissulaire
Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
Similitudes de séquence
Belongs to the eIF-5A family.
Modification post-traductionnelle
Acetylated. Deacetylated by SIRT2.
Localisation cellulaire
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > Nuclear pore complex.
Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Utilisation biotechnologique
Mature eIF5A-1 may be used as an in situ diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.
