EDG5 est un gène codé par le symbole S1PR2. D'autres noms incluent: Sphingosine 1-phosphate receptor 2; S1P receptor 2; Endothelial differentiation G-protein coupled receptor 5; Sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5; S1PR2. EDG5 a une masse de 38.87kDa, une longueur d'acide aminé de 353, et est impliqué dans Deafness, autosomal recessive, 68.
Nous proposons 7 des anticorps contre EDG5, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
Résumé Entrez
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness.
Implication dans la maladie
Deafness, autosomal recessive, 68: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Localisation cellulaire
Cell membrane.
