Anticorps EAAT1

10 produits

EAAT1 est un gène codé par le symbole SLC1A3. D'autres noms incluent: Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3; SLC1A3; GLAST; GLAST1. EAAT1 a une masse de 59.57kDa, une longueur d'acide aminé de 542, et est impliqué dans Episodic ataxia 6.

Nous proposons 10 des anticorps contre EAAT1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.

Informations sur les Gènes et les Protéines

Résumé UniProt
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Résumé Entrez
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911).
Implication dans la maladie
Episodic ataxia 6: A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
Similitudes de séquence
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A3 subfamily.
Modification post-traductionnelle
Glycosylated.
Localisation cellulaire
Cell membrane.
Western Blot - Anti-EAAT1 Antibody [ARC1714] (A306133) - Antibodies.com
(5)
Western Blot - Anti-EAAT1 Antibody (R12-2120) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-EAAT1 Antibody (A90994) - Antibodies.com
Western Blot - Anti-SLC1A3 Antibody (A82700) - Antibodies.com
Western Blot - Anti-SLC1A3 Antibody (A82699) - Antibodies.com
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Anti-EAAT1 Antibody from FabGennix (EAAT1-101AP) - Antibodies.com
(2)
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SLC1A3 Antibody from Signalway Antibody (43457) - Antibodies.com
EAAT1 Positive Control from FabGennix (PC-EAAT1) - Antibodies.com

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