DUSP1 est un gène codé par le symbole DUSP1. D'autres noms incluent: Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; Protein-tyrosine phosphatase CL100; CL100; MKP1; PTPN10; VH1. DUSP1 a une masse de 39.3kDa et une longueur d'acide aminé de 367.
Nous proposons 15 des anticorps contre DUSP1, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Résumé Entrez
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Spécificité tissulaire
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
Similitudes de séquence
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Modification post-traductionnelle
Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
Localisation cellulaire
Nucleus.
