Dopamine Transporter est un gène codé par le symbole SLC6A3. D'autres noms incluent: Sodium-dependent DA transporter; Solute carrier family 6 member 3; SLC6A3; DAT1. Dopamine Transporter a une masse de 68.5kDa, une longueur d'acide aminé de 620, et est impliqué dans Parkinsonism-dystonia infantile.
Nous proposons 8 des anticorps contre Dopamine Transporter, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Résumé Entrez
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Spécificité tissulaire
Highly expressed in substantia nigra.
Implication dans la maladie
Parkinsonism-dystonia infantile: A neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.
Similitudes de séquence
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Localisation cellulaire
Cell membrane.
