Dopamine Receptor D5 est un gène codé par le symbole DRD5. D'autres noms incluent: D(1B) dopamine receptor; D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor; DRD5; DRD1B; DRD1L2. Dopamine Receptor D5 a une masse de 52.95kDa, une longueur d'acide aminé de 477, et est impliqué dans Benign essential blepharospasm.
Nous proposons 12 des anticorps contre Dopamine Receptor D5, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Résumé Entrez
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.
Spécificité tissulaire
Neuron-specific, localized primarily within limbic regions of the brain.
Implication dans la maladie
Benign essential blepharospasm: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Localisation cellulaire
Cell membrane.
