DOK5 est un gène codé par le symbole DOK5. D'autres noms incluent: Docking protein 5; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; C20orf180. DOK5 a une masse de 35.46kDa et une longueur d'acide aminé de 306.
Nous proposons 6 des anticorps contre DOK5, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Résumé Entrez
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Spécificité tissulaire
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Similitudes de séquence
Belongs to the DOK family. Type B subfamily.
Modification post-traductionnelle
Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
