DLK est un gène codé par le symbole DLK1. D'autres noms incluent: Protein delta homolog 1-1; pG21. DLK a une masse de 41.3kDa et une longueur d'acide aminé de 383.
Nous proposons 9 des anticorps contre DLK, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May have a role in neuroendocrine differentiation.
Résumé Entrez
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.
Spécificité tissulaire
Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.
Modification post-traductionnelle
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Localisation cellulaire
Membrane. Cytoplasm.
