Dkk3 est un gène codé par le symbole DKK3. D'autres noms incluent: Dickkopf-related protein 3; Dickkopf-3; REIC. Dkk3 a une masse de 38.39kDa et une longueur d'acide aminé de 350.
Nous proposons 11 des anticorps contre Dkk3, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Résumé Entrez
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Spécificité tissulaire
Highest expression in heart, brain, and spinal cord.
Similitudes de séquence
Belongs to the dickkopf family.
Modification post-traductionnelle
N- and O-glycosylated.
Localisation cellulaire
Secreted.
