DHRS2 est un gène codé par le symbole DHRS2. D'autres noms incluent: Dehydrogenase/reductase SDR family member 2, mitochondrial; Dicarbonyl reductase HEP27; Protein D; Short chain dehydrogenase/reductase family 25C member 1; SDR25C1. DHRS2 a une masse de 29.93kDa et une longueur d'acide aminé de 280.
Nous proposons 6 des anticorps contre DHRS2, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Résumé Entrez
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
Similitudes de séquence
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Localisation cellulaire
Mitochondrion matrix. Nucleus.
A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
