DGAT1 est un gène codé par le symbole DGAT1. D'autres noms incluent: Diacylglycerol O-acyltransferase 1; ACAT-related gene product 1; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Diglyceride acyltransferase; AGRP1; DGAT. DGAT1 a une masse de 55.28kDa, une longueur d'acide aminé de 488, et est impliqué dans Diarrhea 7, protein-losing enteropathy type.
Nous proposons 6 des anticorps contre DGAT1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
Résumé Entrez
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.
Implication dans la maladie
Diarrhea 7, protein-losing enteropathy type: A life-threatening disease characterized by severe, intractable, watery diarrhea.
Similitudes de séquence
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Localisation cellulaire
Endoplasmic reticulum membrane.
