DFFB est un gène codé par le symbole DFFB. D'autres noms incluent: DNA fragmentation factor subunit beta; Caspase-activated deoxyribonuclease; CAD; Caspase-activated nuclease; CPAN; DNA fragmentation factor 40 kDa subunit; DFF-40; DFF2; DFF40. DFFB a une masse de 39.11kDa et une longueur d'acide aminé de 338.
Nous proposons 6 des anticorps contre DFFB, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Résumé Entrez
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
Localisation cellulaire
Cytoplasm. Nucleus.
