Decorin est un gène codé par le symbole DCN. D'autres noms incluent: Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B. Decorin a une masse de 39.75kDa, une longueur d'acide aminé de 359, et est impliqué dans Corneal dystrophy, congenital stromal.
Nous proposons 19 des anticorps contre Decorin, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Poulet et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
May affect the rate of fibrils formation.
Résumé Entrez
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
Implication dans la maladie
Corneal dystrophy, congenital stromal: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
Similitudes de séquence
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Modification post-traductionnelle
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
