DCK est un gène codé par le symbole DCK. D'autres noms incluent: Deoxycytidine kinase; Deoxyadenosine kinase; Deoxyguanosine kinase. DCK a une masse de 30.52kDa et une longueur d'acide aminé de 260.
Nous proposons 12 des anticorps contre DCK, élevé dans Lapin, Souris et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
Résumé Entrez
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Similitudes de séquence
Belongs to the DCK/DGK family.
Modification post-traductionnelle
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
Localisation cellulaire
Nucleus.
