Cytokeratin 8 est un gène codé par le symbole KRT8. D'autres noms incluent: Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8; KRT8; CYK8. Cytokeratin 8 a une masse de 53.7kDa, une longueur d'acide aminé de 483, et est impliqué dans Cirrhosis.
Nous proposons 59 des anticorps contre Cytokeratin 8, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Singe, Mouton, Canin et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Résumé Entrez
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Spécificité tissulaire
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Implication dans la maladie
Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Similitudes de séquence
Belongs to the intermediate filament family.
Modification post-traductionnelle
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Localisation cellulaire
Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
