Cytokeratin 7 est un gène codé par le symbole KRT7. D'autres noms incluent: Keratin, type II cytoskeletal 7; Cytokeratin-7; CK-7; Keratin-7; K7; Sarcolectin; Type-II keratin Kb7; KRT7; SCL. Cytokeratin 7 a une masse de 51.39kDa et une longueur d'acide aminé de 469.
Nous proposons 60 des anticorps contre Cytokeratin 7, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Canin, Félin, Hamster et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Résumé Entrez
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.
Spécificité tissulaire
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
Similitudes de séquence
Belongs to the intermediate filament family.
Modification post-traductionnelle
Arg-20 is dimethylated, probably to asymmetric dimethylarginine.
Localisation cellulaire
Cytoplasm.
