Cytokeratin 5 + 8 est un gène codé par le symbole KRT8. D'autres noms incluent: Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8; KRT8; CYK8. Cytokeratin 5 + 8 a une masse de 53.7kDa, une longueur d'acide aminé de 483, et est impliqué dans Cirrhosis.
Nous proposons 7 des anticorps contre Cytokeratin 5 + 8, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Mouton, Canin, Félin, Furet et Hamster.
Informations sur les Gènes et les Protéines
Résumé UniProt
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Résumé Entrez
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Spécificité tissulaire
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Implication dans la maladie
Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Similitudes de séquence
Belongs to the intermediate filament family.
Modification post-traductionnelle
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Localisation cellulaire
Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
