Cytokeratin 16 est un gène codé par le symbole KRT16. D'autres noms incluent: Keratin, type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16; KRT16; KRT16A. Cytokeratin 16 a une masse de 51.27kDa, une longueur d'acide aminé de 473, et est impliqué dans les maladies: Pachyonychia congenita 1; Keratoderma, palmoplantar, non-epidermolytic, focal 1.
Nous proposons 14 des anticorps contre Cytokeratin 16, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Résumé Entrez
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Spécificité tissulaire
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Implication dans la maladie
Pachyonychia congenita 1: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Keratoderma, palmoplantar, non-epidermolytic, focal 1: A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
Similitudes de séquence
Belongs to the intermediate filament family.
