Cyclin E1 est un gène codé par le symbole CCNE1. D'autres noms incluent: G1/S-specific cyclin-E1; CCNE1; CCNE. Cyclin E1 a une masse de 47.08kDa et une longueur d'acide aminé de 410.
Nous proposons 25 des anticorps contre Cyclin E1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Essential for the control of the cell cycle at the G1/S (start) transition.
Résumé Entrez
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Spécificité tissulaire
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Similitudes de séquence
Belongs to the cyclin family. Cyclin E subfamily.
Modification post-traductionnelle
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Localisation cellulaire
Nucleus.