Cyclin A2 est un gène codé par le symbole CCNA2. D'autres noms incluent: Cyclin-A2; Cyclin-A; Cyclin A; CCNA2; CCN1; CCNA. Cyclin A2 a une masse de 48.55kDa et une longueur d'acide aminé de 432.
Nous proposons 8 des anticorps contre Cyclin A2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Bovin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Résumé Entrez
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M.
Similitudes de séquence
Belongs to the cyclin family. Cyclin AB subfamily.
Modification post-traductionnelle
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Localisation cellulaire
Nucleus. Cytoplasm.
Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
