CTGF est un gène codé par le symbole CCN2. D'autres noms incluent: CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; CCN2; HCS24; IGFBP8. CTGF a une masse de 38.09kDa et une longueur d'acide aminé de 349.
Nous proposons 19 des anticorps contre CTGF, élevé dans Lapin, Souris, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Lapin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Résumé Entrez
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Spécificité tissulaire
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Similitudes de séquence
Belongs to the CCN family.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix. Secreted.
