CtBP1 est un gène codé par le symbole CTBP1. D'autres noms incluent: C-terminal-binding protein 1; CTBP. CtBP1 a une masse de 47.54kDa, une longueur d'acide aminé de 440, et est impliqué dans Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome.
Nous proposons 15 des anticorps contre CtBP1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Résumé Entrez
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Spécificité tissulaire
Expressed in germinal center B-cells.
Implication dans la maladie
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome: An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.
Similitudes de séquence
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Modification post-traductionnelle
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
Localisation cellulaire
Cytoplasm. Nucleus.
