Crk p38 est un gène codé par le symbole CRK. D'autres noms incluent: Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK. Crk p38 a une masse de 33.83kDa et une longueur d'acide aminé de 304.
Nous proposons 10 des anticorps contre Crk p38, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Lapin, Singe et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Résumé Entrez
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Similitudes de séquence
Belongs to the CRK family.
Modification post-traductionnelle
Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:17515907). Isoform Crk-II: Phosphorylated by KIT (By similarity).
Localisation cellulaire
Cytoplasm. Cell membrane.
Translocated to the plasma membrane upon cell adhesion.
