CRF1 est un gène codé par le symbole CRHR1. D'autres noms incluent: Corticotropin-releasing factor receptor 1; CRF-R-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRHR1; CRFR; CRFR1; CRHR. CRF1 a une masse de 50.72kDa et une longueur d'acide aminé de 444.
Nous proposons 4 des anticorps contre CRF1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Résumé Entrez
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene.
Spécificité tissulaire
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
Similitudes de séquence
Belongs to the G-protein coupled receptor 2 family.
Modification post-traductionnelle
C-terminal Ser or Thr residues may be phosphorylated.
Localisation cellulaire
Cell membrane. Endosome.
Agonist-binding promotes endocytosis.