CREM est un gène codé par le symbole CREM. D'autres noms incluent: cAMP-responsive element modulator; Inducible cAMP early repressor; ICER. CREM a une masse de 37.01kDa et une longueur d'acide aminé de 345.
Nous proposons 6 des anticorps contre CREM, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Résumé Entrez
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Spécificité tissulaire
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Similitudes de séquence
Belongs to the bZIP family.
Modification post-traductionnelle
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Localisation cellulaire
Nucleus.
