CRABP2 est un gène codé par le symbole CRABP2. D'autres noms incluent: Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II. CRABP2 a une masse de 15.69kDa et une longueur d'acide aminé de 138.
Nous proposons 10 des anticorps contre CRABP2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Résumé Entrez
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Similitudes de séquence
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Modification post-traductionnelle
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Localisation cellulaire
Cytoplasm. Endoplasmic reticulum. Nucleus.
Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
