CLEC12A est un gène codé par le symbole CLEC12A. D'autres noms incluent: C-type lectin domain family 12 member A; C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Myeloid inhibitory C-type lectin-like receptor; MICL; CLL1; DCAL2. CLEC12A a une masse de 30.76kDa et une longueur d'acide aminé de 265.
Nous proposons 6 des anticorps contre CLEC12A, élevé dans Lapin, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Résumé Entrez
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
Spécificité tissulaire
Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Modification post-traductionnelle
Highly N-glycosylated. Glycosylation varies between cell types.
Localisation cellulaire
Cell membrane.
Ligand binding leads to internalization.
