Claudin 7 est un gène codé par le symbole CLDN7. D'autres noms incluent: Claudin-7; CLDN-7; CLDN7; CEPTRL2; CPETRL2. Claudin 7 a une masse de 22.42kDa et une longueur d'acide aminé de 211.
Nous proposons 12 des anticorps contre Claudin 7, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space.
Résumé Entrez
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
Spécificité tissulaire
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Similitudes de séquence
Belongs to the claudin family.
Modification post-traductionnelle
Phosphorylated.
Localisation cellulaire
Cell membrane. Basolateral cell membrane. Cell junction > Tight junction.
Co-localizes with EPCAM at the basolateral cell membrane and tight junction.
