Claudin 6 est un gène codé par le symbole CLDN6. D'autres noms incluent: Claudin-6; Skullin; CLDN6. Claudin 6 a une masse de 23.29kDa et une longueur d'acide aminé de 220.
Nous proposons 13 des anticorps contre Claudin 6, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space.
Résumé Entrez
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Spécificité tissulaire
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Similitudes de séquence
Belongs to the claudin family.
Localisation cellulaire
Cell junction > Tight junction. Cell membrane.
