Claudin 4 est un gène codé par le symbole CLDN4. D'autres noms incluent: Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; Williams-Beuren syndrome chromosomal region 8 protein; CLDN4; CPER; CPETR1; WBSCR8. Claudin 4 a une masse de 22.08kDa et une longueur d'acide aminé de 209.
Nous proposons 12 des anticorps contre Claudin 4, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Résumé Entrez
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Similitudes de séquence
Belongs to the claudin family.
Modification post-traductionnelle
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Localisation cellulaire
Cell junction > Tight junction. Cell membrane.
CLDN4 is required for tight junction localization in the kidney.
