Claudin 2 est un gène codé par le symbole CLDN2. D'autres noms incluent: Claudin-2; SP82; CLDN2. Claudin 2 a une masse de 24.55kDa et une longueur d'acide aminé de 230.
Nous proposons 7 des anticorps contre Claudin 2, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Résumé Entrez
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
Similitudes de séquence
Belongs to the claudin family.
Modification post-traductionnelle
The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
Localisation cellulaire
Cell junction > Tight junction. Cell membrane.
