Clathrin light chain est un gène codé par le symbole CLTA. D'autres noms incluent: Clathrin light chain A; Lca; CLTA. Clathrin light chain a une masse de 27.08kDa et une longueur d'acide aminé de 248.
Nous proposons 9 des anticorps contre Clathrin light chain, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
Résumé Entrez
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.
Similitudes de séquence
Belongs to the clathrin light chain family.
Localisation cellulaire
Cytoplasmic vesicle membrane. Membrane > Coated pit. Cytoplasm > Cytoskeleton > Spindle.
Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
