CES2 est un gène codé par le symbole CES2. D'autres noms incluent: Cocaine esterase; Carboxylesterase 2; CE-2; Methylumbelliferyl-acetate deacetylase 2; ICE. CES2 a une masse de 61.81kDa et une longueur d'acide aminé de 559.
Nous proposons 6 des anticorps contre CES2, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Résumé Entrez
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.
Spécificité tissulaire
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Similitudes de séquence
Belongs to the type-B carboxylesterase/lipase family.
Modification post-traductionnelle
Glycosylated.
Localisation cellulaire
Endoplasmic reticulum lumen.
