CEACAM5 est un gène codé par le symbole CEACAM5. D'autres noms incluent: Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100. CEACAM5 a une masse de 76.8kDa et une longueur d'acide aminé de 702.
Nous proposons 76 des anticorps contre CEACAM5, élevé dans Lapin, Souris, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et RIA avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Résumé Entrez
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. CEA family.
Modification post-traductionnelle
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Localisation cellulaire
Cell membrane. Apical cell membrane. Cell surface.
Localized to the apical glycocalyx surface.
