Cdc6 est un gène codé par le symbole CDC6. D'autres noms incluent: Cell division control protein 6 homolog-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC18L. Cdc6 a une masse de 62.72kDa, une longueur d'acide aminé de 560, et est impliqué dans Meier-Gorlin syndrome 5.
Nous proposons 10 des anticorps contre Cdc6, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Résumé Entrez
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
Implication dans la maladie
Meier-Gorlin syndrome 5: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
Similitudes de séquence
Belongs to the CDC6/cdc18 family.
Localisation cellulaire
Nucleus. Cytoplasm.
The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).