Cdc37 est un gène codé par le symbole CDC37. D'autres noms incluent: Hsp90 co-chaperone Hsp90 chaperone protein kinase-targeting subunit; p50CDC37A. Cdc37 a une masse de 44.47kDa et une longueur d'acide aminé de 378.
Nous proposons 14 des anticorps contre Cdc37, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et S. cerevisiae.
Informations sur les Gènes et les Protéines
Résumé UniProt
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Résumé Entrez
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Similitudes de séquence
Belongs to the CDC37 family.
Modification post-traductionnelle
Constitutively sumoylated by UBE2I.
Localisation cellulaire
Cytoplasm.
