CD62L est un gène codé par le symbole SELL. D'autres noms incluent: L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; SELL; LNHR; LYAM1. CD62L a une masse de 42.19kDa et une longueur d'acide aminé de 372.
Nous proposons 33 des anticorps contre CD62L, élevé dans Lapin, Souris et Rat, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Mouton et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Résumé Entrez
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Spécificité tissulaire
Expressed in B-cell lines and T-lymphocytes.
Similitudes de séquence
Belongs to the selectin/LECAM family.
Modification post-traductionnelle
N-glycosylated.
Localisation cellulaire
Cell membrane.
