CD53 est un gène codé par le symbole CD53. D'autres noms incluent: Leukocyte surface antigen Cell surface glycoprotein Tetraspanin-25; Tspan-25; MOX44; TSPAN25. CD53 a une masse de 24.34kDa et une longueur d'acide aminé de 219.
Nous proposons 12 des anticorps contre CD53, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Résumé Entrez
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
Similitudes de séquence
Belongs to the tetraspanin (TM4SF) family.
Localisation cellulaire
Cell membrane. Cell junction. Membrane.
Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
