CD33 est un gène codé par le symbole CD33. D'autres noms incluent: Myeloid cell surface antigen Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; SIGLEC3. CD33 a une masse de 39.83kDa et une longueur d'acide aminé de 364.
Nous proposons 45 des anticorps contre CD33, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).
Spécificité tissulaire
Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Modification post-traductionnelle
Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition.
Localisation cellulaire
Cell membrane.
