CD27 est un gène codé par le symbole CD27. D'autres noms incluent: CD27 antigenL receptor; T-cell activation antigen T14; Tumor necrosis factor receptor superfamily member 7; TNFRSF7. CD27 a une masse de 29.14kDa, une longueur d'acide aminé de 260, et est impliqué dans Lymphoproliferative syndrome 2.
Nous proposons 58 des anticorps contre CD27, élevé dans Lapin, Souris, Chèvre, Hamster et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Résumé Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Spécificité tissulaire
Found in most T-lymphocytes.
Implication dans la maladie
Lymphoproliferative syndrome 2: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Modification post-traductionnelle
Phosphorylated.
Localisation cellulaire
Membrane.
