CD20 est un gène codé par le symbole MS4A1. D'autres noms incluent: B-lymphocyte antigen B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1. CD20 a une masse de 33.08kDa, une longueur d'acide aminé de 297, et est impliqué dans Immunodeficiency, common variable, 5.
Nous proposons 108 des anticorps contre CD20, élevé dans Lapin, Souris, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe, Canin et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Résumé Entrez
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Spécificité tissulaire
Expressed on B-cells.
Implication dans la maladie
Immunodeficiency, common variable, 5: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Similitudes de séquence
Belongs to the MS4A family.
Modification post-traductionnelle
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
Localisation cellulaire
Cell membrane. Cell membrane.
Constitutively associated with membrane rafts.
